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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Study period:
No data
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions

Data source

Reference Type:
The protective roles of vitamins A and D against excess intake of boric acid in vivo.
Geyikoglu F, Turkez H, Topal A, Keles MS & Ozkan A
Bibliographic source:
Proceedings of 3rd International Boron Symposium 02-04 November 2006, Ankara.

Materials and methods

Type of study / information:
The intraperitoneal effects of different boric acid concentrations were assessed.
Test guideline
according to guideline
other: No data
not specified
Principles of method if other than guideline:
The intraperitoneal effects of different boric acid concentrations on concentrations of serum enzymes, haematological parameters and liver histology were assessed.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Boric acid
Boric acid
Details on test material:
- Name of test material: Boric acid

Results and discussion

Applicant's summary and conclusion

Haematological parameters slightly decreased with exposure to 750 mg/kg boric acid at 48 h but all values were not significantly different from controls. LDH and hepatocytes were unchanged. At low doses of boric acid levels of ALT, ALP and LDH as AST were unsignificantly decreased at 48 h.