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EC number: 201-122-9 | CAS number: 78-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The original study is not available, however this study was peer reviewed and included in two reference books.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Tris(2-butoxyethyl) phosphate
- EC Number:
- 201-122-9
- EC Name:
- Tris(2-butoxyethyl) phosphate
- Cas Number:
- 78-51-3
- Molecular formula:
- C18H39O7P
- IUPAC Name:
- tris(2-butoxyethyl) phosphate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- Days 6-15 of gestation
- Frequency of treatment:
- once per day
- No. of animals per sex per dose:
- 25
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Sex: female
Duration of test: 10-days
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Remarks on result:
- other: No data
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 500 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
There were signs of maternal toxicity in the rats dosed at 1500 mg/kg/day including reduced grooming, ataxia, reduced body weight gain and lethargy, and one death was recorded. Treatment with TBEP in corn oil had no effect at any dose level on foetal resorption, foetal viability, post-implantation loss, total implantations or the incidence of foetal malformations.
Applicant's summary and conclusion
- Conclusions:
- NOEL (maternal): 500 mg/kg bw/day
NOEL (development): 1500 mg/kg bw/day
Exposure of pregnant rats to TBEP during organogenesis did not affect embryofoetal development. - Executive summary:
In a developmental toxicity study, TBEP was administered by gavage in corn oil to three groups of 25 mated Charles River CD female rats at dose levels of 250, 500 and 1500 mg/kg bw/day on days 6 to 15 of gestation. A fourth group served as a vehicle control. Maternal weight gain was depressed only in the high-dose group. The treatment had no effect at any dose level on foetal resorption, foetal viability, post-implantation loss, total implantations or incidence of foetal malformations.
The original study report was not available, however the principal data are summarised in two peer-reviewed publications. The published report is considered adequate to cover the requirements for this endpoint.
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