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EC number: 201-122-9 | CAS number: 78-51-3
In a modified Buehler test, 10 albino guinea pigs were exposed to TBEP. A 0.5 ml portion of test material was applied to the intact skin test sites. A gauze patch was placed over the treated area and an impervious material was wrapped snugly around the trunks of the animals. After a 24 hour contact period, the patch was removed and the animals were allowed to rest for one day. Following the rest period, another application was made to the same skin site using a fresh test sample. This sequence was repeated for a total of ten applications. The animals were then rested for two weeks. At the end of the rest period, a challenge application was made to a fresh skin site and left on the skin for 24 hours. 24 hours after each induction stage application and 24 and 48 hours after the challenge application, the sites were examined for irritation, using the Draize method of scoring.
There were no signs of irritation at any of the test sites during induction or at challenge. It was concluded that TBEP was not a primary skin irritant or sensitizing agent in the albino guinea pig.
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