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EC number: 201-122-9 | CAS number: 78-51-3
The test article, MCTR-16 -79 (tris(2-butoxyethyl) phosphate) was evaluated for acute dermal toxicity in groups of male and female New Zealand White rabbits. Half of the animals in each test group (4M + 4F) had an area of exposed skin (for subsequent dosing) abraded with minor incisions sufficiently deep to penetrate the stratum corneum but not deep enough to disturb the dermis or produce bleeding. The skin of the remaining rabbits was left intact. The test substance was left in contact with the skin for 24-h under a non-absorbent binder. Dermal effects recorded following exposure were scored on days 1, 3, 7, 10 and 14 according to Draize. Surviving animals were killed on day 14 and a post-mortem examination was conducted.
One female animal of the 5000 mg/kg group was found dead on day 7. The only systemic clinical effects reported were slight to marked anorexia in all groups and eye discharge in a single mid-dose male. Local effects including erythema, oedema, blanching and epidermal scaling were reported.
According to the results of this study, the dermal LD50 is > 5000 mg/kg.
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