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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1983
Reference Type:
publication
Title:
Unnamed
Year:
1986
Reference Type:
publication
Title:
Triaryl/alkyl phosphate residues in human adipose tissue autopsy samples from six Ontario municipalities
Author:
Lebel GL, Williams DT, Berard D
Year:
1989
Bibliographic source:
Bull. Environ. Contam. Toxicol., 43: 225-230.

Materials and methods

Type of study / information:
Concentration in adipose tissue
Endpoint addressed:
basic toxicokinetics
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Post-mortem extraction of adipose tissue, with analytical analysis for TBEP concentration.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-butoxyethyl) phosphate
EC Number:
201-122-9
EC Name:
Tris(2-butoxyethyl) phosphate
Cas Number:
78-51-3
Molecular formula:
C18H39O7P
IUPAC Name:
tris(2-butoxyethyl) phosphate

Method

Exposure assessment:
measured

Results and discussion

Results:
Concentration of TBEP ranged from 25 to 483 ng/g adipose tissue (individual values).
1983: TBEP mean concentration: 4.0 - 26.8 ng/g (4/16 samples)
1986: TBEP found in 21/68 male and 20/47 female samples
1989: TBEP overall mean concentration (41 samples): 11.3 ng/g (male=6.3; female=16.6 ng/g).
Ottawa: mean 15.8 ng/g (male+female); 28.6 ng/g (female); 7.9 ng/g (male)
Kingston: mean 6.6 ng/g (male+female); 8.7 ng/g (female); 3.6 ng/g (male)

Any other information on results incl. tables

TBEP was only detected in 3/6Ontario municipalities.

 

Table 1: Mean and range concentrations of TBEP (ng/g) in humans from Ontario.

 

Site

Sex

No

Mean

Range

Frequency

London

M

8

ND

ND

ND

London

F

8

25

ND

1/8

Toronto

M

4

425

400-483

4/4

Toronto

F

3

357

320-424

3/3

Toronto

M+F

7

396

320-483

7/7

Cornwall

M

8

165

ND-202

3/8

Cornwall

F

5

198

ND

1/5

Cornwall

M+F

13

173

ND-202

4/13


In Lebel & Williams (1983) 4 of 16 human adipose tissue samples were found to contain TBEP at levels of between 4.0 and 26.8 µg/kg.

 

In a later similar study (Lebel & Williams, 1986) of 115 samples obtained at autopsy from Kingston (58) and Ottawa (57), TBEP was found in 21/68 male samples and 20/47 female samples.

 

Table 2: Mean concentrations of TBEP in humans from Ottawa.

 

Site

Sex

Mean

Range (ng/g)

Kingston

M

3.6

0.7-12.9

Kingston

F

8.7

1.5-26.8

Kingston

M+F

6.6

0.7-26.8

Ottawa

M

7.9

1.0-21.7

Ottawa

F

28.6

0.9-142.2

Ottawa

M+F

15.8

0.9-142.2

 

The mean concentrations of TBEP in Ottawa were 2.5 -times those found in the Kingston samples. In both cities the TBEP level in females was 2-3-times that of the male samples.

The mean TBEP concentration in the 41 samples was 11.3 micrograms/kg (male=6.3; female=16.6 micrograms/kg).

Applicant's summary and conclusion

Conclusions:
Absorbed TBEP is distributed through the body and is present at low concentrations in adipose tissue.