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Diss Factsheets
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EC number: 201-122-9 | CAS number: 78-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
OECD Guideline 203, EU Method C1, no-GLP, key study, validity 2: 96h-LC50 = 24 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 24 mg/L
Additional information
Available data on short-term toxicity to fish
Four studies were recorded for the endpoint short-term toxicity to fish. An overview of this dataset is provided in the table below:
Method |
Species |
Basis for effect |
Endpoint |
Effect concentration |
Reliability |
Reference |
OECD 203 EC Method C.1 |
Oncorhynchus mykiss |
Mortality |
96h-LC50 96h-NOEC |
=24 mg/L (n) =10 mg/L (n) |
2 |
Wetton PM & Handley JW (1998) |
OPTS EPA 560/6-002 (1982) |
Pimephales promelas |
Mortality |
96h-LC50 96h-NOEC |
=16 mg/L (n) =7.8 mg/L (n) |
2 |
Sousa JV & Holling JP (1984) |
JIS K 0102-1986-71 |
Oryzias latipes |
Mortality |
48h-LC50 (10°C) 48h-LC50 (20°C) 48h-LC50 (30°C) |
=44 mg/L (n) =27 mg/L (n) =6.8 mg/L (n) |
2 |
Tsuji S et al (1986) |
OECD 203
|
Pimephales promelas |
Mortality |
96h-LC50 |
=11.2 mg/L (m) |
2 |
Geiger DL et al (1986) |
n: nominal concentration - m: measured concentration
Sensitivity of fish to TBEP exposure
For the three species, the toxicity parameters (96h-LC50, 48h-LC50) were in the same order of magnitude ie from 10 mg/L to 100 mg/L. The short-term toxicity to fish of TBEP is increased by temperature (Tsuji et al., 1986) which is a conventional pattern.
Selection of the key study
The study of Wetton and Handley (1998) was flagged as key study for this endpoint.
Conclusion
Based on the available dataset, tris(2 -butoxyethyl) phosphate would be classified as harmful to freshwater fish in accordance with the classification system of EU (Directive 67/548/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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