Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

OECD Guideline 203, EU Method C1, no-GLP, key study, validity 2: 96h-LC50 = 24 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
24 mg/L

Additional information

Available data on short-term toxicity to fish

Four studies were recorded for the endpoint short-term toxicity to fish. An overview of this dataset is provided in the table below:

Method

Species

Basis for effect

Endpoint

Effect concentration

Reliability

Reference

OECD 203

EC Method C.1

Oncorhynchus mykiss

Mortality

96h-LC50

96h-NOEC

=24 mg/L (n)

=10 mg/L (n)

2

Wetton PM & Handley JW (1998)

OPTS EPA 560/6-002 (1982)

Pimephales promelas

Mortality

96h-LC50

96h-NOEC

=16 mg/L (n)

=7.8 mg/L (n)

2

Sousa JV & Holling JP (1984)

JIS K 0102-1986-71

Oryzias latipes

Mortality

48h-LC50 (10°C)

48h-LC50

(20°C)

48h-LC50

(30°C)

=44 mg/L (n)

=27 mg/L (n)

=6.8 mg/L (n)

2

Tsuji S et al (1986)

OECD 203

 

Pimephales promelas

Mortality

96h-LC50

=11.2 mg/L (m)

2

Geiger DL et al (1986)

n: nominal concentration - m: measured concentration

Sensitivity of fish to TBEP exposure

For the three species, the toxicity parameters (96h-LC50, 48h-LC50) were in the same order of magnitude ie from 10 mg/L to 100 mg/L. The short-term toxicity to fish of TBEP is increased by temperature (Tsuji et al., 1986) which is a conventional pattern.

Selection of the key study

The study of Wetton and Handley (1998) was flagged as key study for this endpoint.

Conclusion

Based on the available dataset, tris(2 -butoxyethyl) phosphate would be classified as harmful to freshwater fish in accordance with the classification system of EU (Directive 67/548/EC).