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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06 March - 21 March, 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. certificate)
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
- Sampling intervals for the parent/transformation products:
- Sampling method: sample solutions were prepared in stoppered glass flasks at a nominal concentration of 2 g/L in the three buffer solutions. The solutions were shielded from light whilst maintained at the test temperature.
- Sampling methods for the volatile compounds, if any:
- Sampling intervals/times for pH measurements:
- Sampling intervals/times for sterility check:
- Sample storage conditions before analysis:
- Other observation, if any (e.g.: precipitation, color change etc.):
Buffers:
- pH: 4, 7 and 9
- Composition of buffer: Buffer solution 4: Citric acid (0.013 mol/dm3), sodium hydroxide (0.025 mol/dm3), hydrochloric acid (0.013 mol/dm3); bufer solution 7: disodium hydrogen phosphate (0.01 mol/dm3), potassium dihydrogen phosphate (0.008 mol/dm3); buffer solution 9: disodium tetraborate (0.013 mol/dm3), hydrochloric acid (0.005 mol/dm3)
Duration:
120 h
Number of replicates:
2
Transformation products:
not measured
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Details on results:
TEST CONDITIONS

MINOR TRANSFORMATION PRODUCTS
Maximum concentrations in % of the applied amount
- at pH4: 1.99 g/L
- at pH7: 2.36 g/L
- at pH9: 2.66 g/L

Validity criteria fulfilled:
yes
Conclusions:
There was less than 10% hydrolysis after 5 days at 50°C at pH 4, 7 and 9. The estimated half-lives at 25°C of NINOX HCDO at pH 4, 7 and 9 are > 1 year.

Description of key information

The key value for hydrolysis was obtained from a 5 day test at pH 4, 7 and 9 and 25 °C.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

There was less than 10% hydrolysis after 5 days at 50°C at pH 4, 7 and 9. The estimated half-lives at 25°C of 3 -C12-18 -(even numbered)-alkyl amido-N,N-dimethylpropan-1 -amine oxide at pH 4, 7 and 9 are > 1 year.