Registration Dossier

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29/06/2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
other: liquid bath method
Melting / freezing pt.:
86.6 - 96.4 °C
Remarks on result:
other: Run 1: Initial Melting Point: 86.6 °C and Final Melting Point: 96.4°C; atmospheric pressure not reported; ambient conditions are anticipated
Melting / freezing pt.:
84.9 - 91.3 °C
Remarks on result:
other: Run 2: Initial Melting Point: 84.9°C and Final Melting Point: 91.3°C; atmospheric pressure not reported; ambient conditions are anticipated

The difference in the two initial melting temperatures and the two final melting points is outside the estimated accuracy. However, as the sample is multi-component, has been freeze-dried and cannot be pulverised due to its hygroscopic nature, there cannot be any certainty that the material is homogeneous. Therefore it is not possible to determine the melting range within the limits of accuracy and the highest and lowest temperatures have been reported.

Conclusions:
The melting point temperature range (highest and lowest temperature observed) is 84.9 - 96.4°C.

Description of key information

The melting point of amides, C12-18 (even numbered), N-[3-(dimethylamino)propyl], N'-oxides under ambient conditions was determined to be in the range (highest and lowest temperature observed) of 84.9 - 96.4°C in a GLP study according to test method EC A.1 (Younis, 2013).

Key value for chemical safety assessment

Additional information

Value used for CSA: 84.9 - 96.4°C.