Registration Dossier
Registration Dossier
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EC number: 202-640-8 | CAS number: 98-13-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- no data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study did not meet current guideline requirements for acute eye irritation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two methods were employed; A 3 minute exposure of the eye to the substantially saturated vapour of the test substance, and an instillation of the test substance into the eye in liquid form.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trichloro(phenyl)silane
- EC Number:
- 202-640-8
- EC Name:
- Trichloro(phenyl)silane
- Cas Number:
- 98-13-5
- Molecular formula:
- C6H5Cl3Si
- IUPAC Name:
- trichloro(phenyl)silane
- Details on test material:
- No data.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- No data on the single instillation into the eye. The vapour exposure was 3 minutes.
- Observation period (in vivo):
- No data on the single instillation into the eye. The vapour exposure observation period was 7 days.
- Number of animals or in vitro replicates:
- No data.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Corneal burns (see method)
- Remarks on result:
- other: Grade 9 Corneal burns, in response to instillation into the eye.
Any other information on results incl. tables
Minimum concentration of vapour that caused no immediate damage to the rabbit eye but resulted in an increase of at least 20% necrosis of the cornea during subsequent staining with fluorescein after 3,24,48 hours and after 7 days was found to be 250ppm.
Applicant's summary and conclusion
- Conclusions:
- The study did not meet current guideline requirements for eye irritation.
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