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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Remarks:
no data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not meet current guideline requirements for acute eye irritation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report Date:
1951

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Two methods were employed; A 3 minute exposure of the eye to the substantially saturated vapour of the test substance, and an instillation of the test substance into the eye in liquid form.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data.

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
No data on the single instillation into the eye. The vapour exposure was 3 minutes.
Observation period (in vivo):
No data on the single instillation into the eye. The vapour exposure observation period was 7 days.
Number of animals or in vitro replicates:
No data.

Results and discussion

In vivo

Results
Irritation parameter:
other: Corneal burns (see method)
Remarks on result:
other: Grade 9 Corneal burns, in response to instillation into the eye.

Any other information on results incl. tables

Minimum concentration of vapour that caused no immediate damage to the rabbit eye but resulted in an increase of at least 20% necrosis of the cornea during subsequent staining with fluorescein after 3,24,48 hours and after 7 days was found to be 250ppm.

Applicant's summary and conclusion

Conclusions:
The study did not meet current guideline requirements for eye irritation.