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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1951
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not meet current guideline requirements for acute inhalation toxicity. It does however add weight of evidence for trichloro(phenyl)silane toxicity.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report Date:
1951

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Two methods were employed in determining inhalation toxicity; 1. A 4 hour exposure exposure of 6 rats to 500 and 1000 ppm vapour. 2. Exposure of 6 rats to substantially saturated vapour at room temperature, and the time it took til death.
GLP compliance:
not specified
Test type:
other:
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
1.500, 1000 ppm
2. Substantially saturated vapour.
No. of animals per sex per dose:
6 animals/dose, sex unspecified
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
discriminating conc.
Exp. duration:
5 min
Remarks on result:
other: Time to death for all animals when exposed to substantially saturated vapour

Any other information on results incl. tables

Table 1: Concentrations and mortality per animals treated

Nominal

Conc. (ppm)

Mortality (# dead/total)

 1000

 

3/6 

 

 500

 

 1/6

 

 

Applicant's summary and conclusion

Conclusions:
The mortality data presented here was determined in a study which did not meet current guideline requirements for inhalation toxicity. No LC50 was derived. It does however add to the weight of evidence of trichloro(phenyl)silane toxicity.