Registration Dossier

Administrative data

Description of key information

There are no data for skin and eye irritation/corrosion for trichloro(octyl)silane. However, based on the fact that this substance is a chlorosilane, generating hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VIII, the in vitro skin and eye irritation studies (required in Section 7.3.1 and 7.3.2) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Trichloro(octyl)silane hydrolyses very rapidly in contact with water and moist air, releasing three moles of hydrochloric acid (HCl) for each mole of parent material. Although no reliable irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of hydrochloric acid. This is consistent with reliable measured data for other chlorosilanes.


Justification for classification or non-classification

Based on the available information, trichloro(octyl)silane requires classification Skin Corr. 1A and Eye Damage 1, H314 ‘Causes severe skin burns and eye damage’ according to Regulation (EC) No 1272/2008. .

There are no experimental data for skin or eye irritation/corrosion. Trichloro(octyl)silane hydrolyses very rapidly in contact with water and moist air, releasing three moles of hydrochloric acid (HCl) for each mole of parent material. Although no reliable irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of hydrochloric acid. This is consistent with reliable measured data for other chlorosilanes.

There are no experimental data for respiratory tract irritation but the additional hazard statement EUH071 ‘corrosive to the respiratory tract' (Regulation (EC) No 1272/2008) is proposed in accordance with anticipated respiratory tract damage due to the hydrolysis product hydrochloric acid generated by chlorosilanes on contact with moisture.