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EC number: 235-804-2 | CAS number: 12767-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07/09/1990 to 21/09/1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA (40 CFR)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA (40 CFR)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: OECD - Not specified
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Hexaboron dizinc undecaoxide
- EC Number:
- 235-804-2
- EC Name:
- Hexaboron dizinc undecaoxide
- Cas Number:
- 12767-90-7
- Molecular formula:
- B6O11Zn2
- IUPAC Name:
- hexaboron dizinc undecaoxide
- Details on test material:
- - Name of test material: XPI-187 zinc borate
- Physical state: Fine white powder
- Storage condition of test material: At room temperature in a large plastic Nalgene bottle with a lid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague Dawley, Inc.
- Age at study initiation: Young adult
- Weight at study initiation: 228 - 301 g
- Fasting period before study: Overnight
- Housing: In groups of five in wire mesh suspension cages.
- Diet: Ad libitum, except for fasting period.
- Water: Ad libitum
- Acclimation period: At least 4 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 h dark/light cycle.
IN-LIFE DATES: From: 07/09/1990 To: 21/09/1990
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 % w/v - Doses:
- 5 g/kg
- No. of animals per sex per dose:
- Five/sex/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for gross signs of systemic toxicity and mortality several times during the day of dosing and at least twice daily thereafter for a total of 14 days. Body weights were measured for each animal on the day of dosing, on Day 7 and at the time of necropsy.
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs and body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 other: g/kg
- Based on:
- test mat.
- Remarks on result:
- other: The LD50 was greater than the limit dose. No clinically relevant mortality was observed.
- Mortality:
- One death was observed on Day 3 of the observation period but was not deemed clinically relevant.
- Clinical signs:
- other: Clinical signs included faecal stains, depression and unkempt fur.
- Gross pathology:
- No relevant gross pathology was observed. The gross necropsy findings in the animals that died during the observation period were those generally seen in agonal animals.
Any other information on results incl. tables
Body weight data in male and female rats treated orally with a 50 % w/v formulation of XPI-187 zinc borate in corn oil at a dose level of 5.0 g/kg:
Animal No. |
Sex |
Body weight (g) |
Body weight change Day 0 – 14 (g) |
||
Day 0 |
Day 7 |
Day 14 |
|||
1-1761 |
M |
279 |
229a |
ND |
N/A |
2-* |
M |
263 |
323 |
349 |
86 |
3-1763 |
M |
264 |
309 |
343 |
79 |
4-1764 |
M |
301 |
339 |
372 |
71 |
5-1765 |
M |
285 |
238 |
400 |
115 |
Mean (SD) |
278 (16) |
302 (45) |
366 (26) |
88 (19) |
|
6-1766 |
F |
238 |
273 |
278 |
40 |
7-1767 |
F |
249 |
302 |
321 |
72 |
8-1768 |
F |
252 |
305 |
298 |
46 |
9-1769 |
F |
228 |
266 |
271 |
43 |
10-1770 |
F |
241 |
278 |
285 |
44 |
Mean (SD) |
242 (10) |
285 (18) |
291 (20) |
49 (13) |
a body weight taken at death and was not used in the calculation of the mean or standard deviation.
* lost ear tag prior to dosing
ND - No data
N/A - Not applicable
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: other: 40 CFR 156
- Conclusions:
- The acute oral toxicity of XPI-187 zinc borate was evaluated in compliance with the conditions specified in the regulation for the enforcement of the Federal Insecticide, Fungicide and Rodenticide Act (40 CFR), the Toxic Substances Control Act and OECD Guidelines. The acute oral LD50 value was found to be greater than 5.0 g/kg in male and female Sprague-Dawley rats and was greater than the limit dose. The test material was classified in Toxicity Category IV (40 CFR 156) by oral administration.
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