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EC number: 249-951-5 | CAS number: 29911-28-2
The dermal LD50 for dipropylene glycol n-butyl ether is greater than 2,000 mg/kg for male and female Wistar rats.
A group of 5 male and 5 female Wistar rats (~7 weeks old) was treated with a single dose of 2,000 mg/kg dipropylene glycol n-butyl ether applied topically to the intact skin under occlusion for a period of 24 hours. Subjects were observed for clinical signs of toxicity and mortality during the application period and for a period of 14 days after removal of the test material. The skin of the rats at the site of application was also evaluated for signs of irritation over the course of the study. The pure test material was applied at a single dose of 2,000 mg/kg to approximately 10% of the total body surface area of skin (clipped, non-abraded) of the rats. The test material was applied to gauze patches, which were then affixed to the clipped area of the skin and covered with foil and wrapped with a bandage around the torso. The test material was held in contact with the skin for a period of 24 hours whereupon it was removed and the treated area was washed with water to remove remaining test material. On the day of treatment (day 0), animals were observed frequently for toxicity and morbidity. Thereafter, subjects were checked once daily except for weekends and holidays. Individual body weights were recorded on test days 0, 7, and 14. The treated areas of skin were examined on test days 4, 7, and 14 for signs of irritation. Animals were sacrificed on day 14 and subjected to gross necropsy.
No deaths, clinical signs of toxicity, or skin irritation occurred over the course of the study. The dermal LD50 for dipropylene glycol n-butyl ether is greater than 2,000 mg/kg for male and female Wistar rats.
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