Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute toxicity studies in rats, mice, rabbits and guinea pigs
Author:
Moreno OM,
Year:
1976
Bibliographic source:
Unpublished report to RIFM; Tetrahydrolinalool CAS 78-69-3 RIFM ID 773 FEMA 3060
Reference Type:
secondary source
Title:
Acute toxicity studies in rats, mice, rabbits and guinea pigs
Author:
Moreno OM
Year:
1976
Bibliographic source:
cited in: Opdyke DJM, Food Cosmet. Toxicol., Vol 17, p. 909, 1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A dermal LD50 study was conducted in which 5 g/kg of the test material was applied to the skin of 10 rats. The animals were observed for mortality and/or systemic effects for 14 days. No further details were provided.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Tetrahydrolinalool = THL

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw

Applicant's summary and conclusion