Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-133-9 | CAS number: 78-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Oral - rat LD50 = 8270 mg/kg bw (BASF AG 1980)
Dermal - rat LD50 > 5000 mg/kg bw (Moreno 1976)
Inhalation - Rat: IHT: 8h: no mortality in a saturated vapour atmosphere (BASF 1980)
Dermal - Rabbit: LD 50 > 5000 mg/kg bw (Moreno 1976)
Key value for chemical safety assessment
Additional information
Acute oral toxicity:
In the key study, i.e. a limit test, five male and five female Sprague-Dawley rats were treated with 10 ml/kg bw equivalent to approx. 8270 mg/kg bw (BASFAG XXVI402). The animals were observed for 14 d, necropsy was performed with dead animals and survivors. The LD50 was 8270 mg/kg bw for male and female rats. 1/5 males died within 48 h; 3/5 females died within 24 h. Clinical signs of toxicity, i.e dyspnea, apathy, lateral position, staggering, atonia, sedative-like state with loss of corneal and pain reflex, ataxia, spastic movements, diarrhea, salivation and lacrimation, poor general condition and reduced weight gain at beginning of study, were observed. Gross pathology revealed acute dilatation of the heart and slightly brightened kidneys in the deceased animals, whereas in the organs of the sacrificed animals nothing abnormal was detected.
In the supporting study, ten rats (sex was not specified) were administered 5000 mg/kg bw, respectively (Moreno 1976). No mortality was observed, resulting in a LD50 > 5000 mg/kg bw, and the only clinical sign reported was lethargy.
Data on acute oral toxicity in mice, available short reference from secondary source provide an LD50 values of 4500 mg/kg bw (Melceva 1990).
Acute inhalation toxicity:
In a supportive study, i.e. an inhalation hazard test, exposure to an atmosphere
beeing saturated with the volatile part of tetrahydrolinalool at 20°C, 0/12 rats died after 8 h exposure (BASFAG XXVI402). No clinical signs were observed and there were no necropsy findings in the survivors after 2 day observation period.
No key study is available, however, supportive evidence from an inhalation hazard test does not indicate an acute inhalative toxicity of tetrahydrolinalool and a study on acute dermal toxicity, covering a relevant route of exposure, is present.
Acute dermal toxicity:
In the key study, available from secondary sources beeing cited in a peer reviewed publication, tetrahydrolinalool was administered to 10 rabbits (Moreno 1976). The type of coverage was not further specified. The LD50 was reported to be >5000 mg/kg bw.
Acute intraperitoneal toxicity:
Intraperitoneal injection of tetrahydrolinalool in carboxymethyl cellulose to groups of 5 mice per sex and dose resulted in an LD50 of 0.55 ml/kg (approx. 455 mg/kg bw; BASFAG XXVI402).
Taken together, the present data do not indicate an acute toxic potential of tetreahdrolinalool via different routes of exposure.
Justification for classification or non-classification
The present data on acute oral and dermal toxicity do not fulfill the criteria laid down in regulation (EC) 1272/2008, and therefore, a non-classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
