Registration Dossier
Registration Dossier
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EC number: 270-299-2 | CAS number: 68424-38-4 This substance is identified by SDA Substance Name: C16-C18 alkyl carboxylic acid sodium salt and SDA Reporting Number: 19-006-04.
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Fatty acid C16-18, sodium salt
- IUPAC Name:
- Fatty acid C16-18, sodium salt
- Details on test material:
- Batch No: #10-10449
Constituent 1
- Radiolabelling:
- no
Study design
- Details on sampling:
- see below
- Buffers:
- - Buffer pH 4: Potassium hydrogen phthalate
- Buffer pH 7: Potassium dihydrogenphosphate/di-Potassium hydrogenphosphate
- Buffer pH 9: Boric acid /Potassium chloride / Sodium hydroxide - Details on test conditions:
- see below
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- For pH 4, pH 7 and pH 9: The test item hydrolyses completley by immediate protonation to yield the fatty acid. The whole amount of test item is quantified as the corresponding free fatty acid. the recovery rate of the fatty acid is about 100%.
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 100
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 100
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 24 h
- Details on results:
- For pH 4, pH 7 and pH 9: The test item hydrolyses completley by immediate protonation to yield the fatty acid. The whole amount of test item is quantified as the corresponding free fatty acid. the recovery rate of the fatty acid is about 100%.
Any other information on results incl. tables
For pH 4, pH 7 and pH 9: The test item hydrolyses completley by immediate protonation to yield the fatty acid. The whole amount of test item is quantified as the corresponding free fatty acid. the recovery rate of the fatty acid is about 100%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- For pH 4, pH 7 and pH 9: The test item hydrolyses completley by immediate protonation to yield the fatty acid. The whole amount of test item is quantified as the corresponding free fatty acid. the recovery rate of the fatty acid is about 100%.
- Executive summary:
Hydrolysis rate of test item Fatty acid C16 -18, sodium salt as function of pH has been determined according to OECD guideline for the testing of chemicals No 111. The following results could be obtained:
For pH 4, pH 7 and pH 9: The test item hydrolyses completley by immediate protonation to yield the fatty acid. The whole amount of test item is quantified as the corresponding free fatty acid. The recovery rate of the fatty acid is about 100%.
Fatty acid C16-18, sodium salts are not hydrolysed as a function of pH
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