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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no GLP, no guidelined followed
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Type of study / information:
Monitoring report on Workplace exposure
Endpoint addressed:
not applicable
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Samples of air were absorbed to Tenax-GC absorption vials, Desorption with acetonitrile and analysis by GC.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
4,4'-Methylenedianiline, oligomeric reaction products with 1-chloro-2,3-epoxypropane
EC Number:
500-062-3
EC Name:
4,4'-Methylenedianiline, oligomeric reaction products with 1-chloro-2,3-epoxypropane
Cas Number:
28390-91-2
IUPAC Name:
4-[(4-aminophenyl)methyl]aniline; 2-(chloromethyl)oxirane
Details on test material:
not specified

Method

Ethical approval:
not applicable
Details on study design:
The Exposure scenario was developed as follows: Adsorptiion vials were placed 10 cm above the liquid resins containing TGMDA either in glass vesels or on plates impregnated with TGMDA in the laboratory, or in 2-4 litre-chamber s containing prepregs heated to 170°C.
Sampling was always between 5 - 15 minutes depending on the exposure.
Exposure assessment:
measured
Details on exposure:
Several scenarios were evaluated:
Heating in a beaker (130°C), heating under addition of hardener to 130°C, mixing at 130°C, dispersion on glassfibrescreen at 70°C, pressing at 170°C, Hardening at 200 °C in a press.







Results and discussion

Results:
The results of samples taken at a distance of 10 cm were between 0.01 - 0.07 mg/m3 air.
Based on these results it was calculated that MY720 in the laboratory air (Lab: 5 x 7 x 3 m = 105 m3) was below 0.23 mg/m3 airr , and the highest value calculated was 0.07 mg/m3., independent of the heating used.

Any other information on results incl. tables

Individual measurements (all at a distance of 10 cmmeasured):

Heating of MY720 to 50°C in a heating unit:       0.01 mg/m3

Heating of MY720 to 130°C in a beaker:        0.01 mg/m3

Addition of hardener HT-976 to MY 720 (130°C):<0.01 mg/m3

mixing at 130°C:                                                  0.03 mg/m3

Dispersion on fibre glass tissue at 70°C:               0.07 mg/m3

Pressing at 170°C in a box                                   0.01 - 0.02 mg/m3

Hardening in a press at 200°C:                            0.02 mg/m3

Applicant's summary and conclusion

Conclusions:
Tested under laboratory conditions, the air concentration of MY720 never exceeded 0.003 ppm or 0.07 mg/m3 air even at heating to 200°C
Executive summary:

The results of samples taken at a distance of 10 cm were between 0.01 - 0.07 mg/m3 air. Based on these results it was calculated that MY720 in the laboratory air (Lab: 5 x 7 x 3 m = 105 m3) was below 0.23 mg/m3 air , and the highest value calculated was 0.07 mg/m3., independent of the heating used.