Registration Dossier
Registration Dossier
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EC number: 249-204-3 | CAS number: 28768-32-3
Endpoint summary
Administrative data
Description of key information
Additional information
The substance used for read-across (4,4'-methylenedianiline, oligomeric reaction products with 1 -chloro-2,3 -epoxypropane) was found to be toxic to fish (Cyprinus carpio) with a 96h LC50 of 7.0 mg/L in an OECD 203 guideline study.
TGMDA was found to be toxic to Daphnia magna when tested according to OECD 202. The 48h LC50 value was determined to be 6.7 mg/L.
TGMDA was reported to have toxicity to the green algae Pseudokirchnerella subcapitata, with a 72-h ErC50 value for growth rate of 4.8 mg/L and a 72h ErC10 of 0.19 mg/L in an OECD guideline study (Test No. 201).
The substance used for read-across (4,4'-methylenedianiline, oligomeric reaction products with 1 -chloro-2,3 -epoxypropane)
was reported to have low toxicity to microorganisms (activated sludge), with a 24h-IC50 value for growth inhibition greater than 10000 mg/L (nominal). The justification for the read-across approach is given in an Assessment Report in Section 13Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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