Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

4-Nitro-2-methoxy aniline was tested for skin and eye irritation in rabbits in several studies according to OECD guidelines.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Rabbits did not show signs of local irritation when treated with 4 -nitro-2 -methoxy aniline. Neither the dorsal skin nor the eyes reacted with erythema or edema. The minimal effects were confined to 1 of 3 animals on the skin. Ocular treatment caused minimal effects in the conjunctivae of most animals.

Justification for classification or non-classification

No signs of irritation detected.