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Description of key information

A single hydrolysis study (Fischer 2004) exists.  The half-life of hydrolysis at pH 4 and 7 was calculated to be <12h based on preliminary test data.  At pH 9 the half-life was calculated as 

Key value for chemical safety assessment

Half-life for hydrolysis:
220.8 h
at the temperature of:
25 °C

Additional information

The hydrolysis of Trimethylorthoformate was tested according to EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH, 1992). The study is considered valid and conclusive.

A preliminary hydrolysis test was performed for 24 hours at 50°C with the test substance (purity: 99.7%) at pH 4, 7 and 9.

At pH 4 and 7 the hydrolysis was very fast (100 and 97.8% after 1 hour respectively). The main test was triggered at pH 9 since the test substance was hydrolised to 38.5% after 24 hours. Methanol was identified as a transformation product at pH 4, 7 and 9. Methyl formate was identified as degradation product at pH 4 and 7, but not at pH 9.

The main hydrolysis test was performed at pH 9 and at 25 and 50°C. Pseudo first-order rate constants of k = 4.067 x 10E-02 hE-01 and k = 3.139 x 10E-03 hE-01 corresponding to half-lives of t = 17.0 h and t = 220.8 h were calculated respectively for 25 and 50 °C.