Registration Dossier
Registration Dossier
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EC number: 231-718-4 | CAS number: 7699-45-8
Endpoint summary
Administrative data
Description of key information
Zinc chloride is corrosive based on animal skin irritation studies. Due the corrosive nature of zinc chloride to skin, eye irritation studies do not need to be conducted and hence no animal eye irritation data is available on zinc chloride.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Test substance |
Study type |
Species |
Endpoint |
Exposure |
Result |
Remarks |
Reference |
Zinc chloride |
Skin irritation |
Guinea-pig |
Erythema, eschar and oedema formation |
Daily; 0.5 mL of 1% solution; open-patch; 5 days |
Moderately irritating |
2 (reliable with restrictions) key study |
LansdownABG,(1991) |
Zinc chloride |
Skin irritation |
Rabbit |
Erythema, eschar and oedema formation |
Daily; 0.5 mL of 1% solution; open-patch; 5 days |
Severely irritating |
2 (reliable with restrictions) key study |
LansdownABG,(1991) |
Zinc chloride |
Skin irritation |
Rabbit |
Erythema, eschar and oedema formation |
Daily; 0.5 mL of 1% solution; occluded; 5 days |
Severely irritating |
2 (reliable with restrictions) key study |
LansdownABG,(1991) |
Zinc chloride |
Skin irritation |
Mouse |
Erythema, eschar and oedema formation |
Daily; 0.5 mL of 1% solution; open-patch; 5 days |
Severely irritating |
2 (reliable with restrictions) key study |
LansdownABG,(1991) |
Zinc sulphate |
Skin irritation |
Rabbit |
Erythema, eschar and oedema formation |
0.5g; moistened substance; semi-occlusive; 4 hours |
Not irritating |
2 (reliable with restrictions) key study
|
Van Huygevoort AHBM (1999b) |
Zinc sulphate |
Skin irritation |
Rabbit |
Erythema, eschar and oedema formation |
Daily; 0.5 mL; open-patch; 5 days |
Not irritating |
2 (reliable with restrictions) key study
|
LansdownABG,(1991) |
Zinc sulphate |
Skin irritation |
Guinea Pig |
Erythema, eschar and oedema formation |
Daily; 0.5 mL; open-patch; 5 days |
Not irritating |
2 (reliable with restrictions) key study |
LansdownABG,(1991) |
Zinc sulphate |
Skin irritation |
Mouse |
Erythema, eschar and oedema formation |
Daily; 0.5 mL; open-patch; 5 days |
Not irritating |
2 (reliable with restrictions) key study |
LansdownABG,(1991) |
Zinc oxide |
Skin irritation |
Rabbit |
Erythema, eschar and oedema formation |
500 mg; occlusive; 24 hours |
Not irritating |
2 (reliable with restrictions) key study
|
Löser, (1977) |
Zinc oxide |
Skin irritation |
Rabbit |
Erythema, eschar and oedema formation |
Daily; 0.5 mL; occlusive; 5 days |
Not irritating |
2 (reliable with restrictions) key study
|
LansdownABG,(1991) |
Zinc oxide |
Skin irritation |
Rabbit |
Erythema, eschar and oedema formation |
Daily; 0.5 mL; open patch; 5 days |
Not irritating |
2 (reliable with restrictions) key study
|
LansdownABG,(1991) |
Zinc oxide |
Skin irritation |
Guinea-pig |
Erythema, eschar and oedema formation |
Daily; 0.5 mL; open |
Not irritating |
2 (reliable with restrictions) key study
|
LansdownABG,(1991) |
Zinc oxide |
Skin irritation |
Mouse |
Erythema, eschar and oedema formation |
Daily; 0.5 mL; open |
Not irritating |
2 (reliable with restrictions) key study
|
LansdownABG,(1991) |
Effects on skin irritation/corrosion: highly irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Based on the available data of the soluble zinc compounds, soluble zinc chloride is classified as corrosive (C;R34) according to EC criteria due to severe skin irritancy seen in animals at concentrations of 1% solution and irreversible damage to eyes caused by zinc chloride after accidental exposure in humans. Zinc chloride has also shown signs of respiratory tract irritation in single exposure studies (see acute inhalation toxicity).
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