Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Soluble zinc chloride is harmful following acute oral exposure (LD50 range 1,100 to 1,260 mg/kg bw) and is classified as harmful if swallowed (Xn; R22) according EC criteria (Council Directive 67/548/EEC). Zinc chloride has also demonstrated acute toxicity via the inhalation route (LC50 ≤ 1,975 mg/m3). However, since the exposure of the animals to the size of the particles is not truly representative of exposure to humans under normal conditions, it is difficult to assess whether or not, zinc chloride is acutely toxic since a four hour LC50 value could not be derived and a clear dose-response relationhip coud not be established. Airway irritation has been observed both in animals and in humans, zinc chloride has the potential to be a respiratory tract irritant.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
1 100 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
discriminating conc.
Value:
2 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Soluble zinc chloride is harmful following acute oral exposure (LD50 range 1,100 to 1,260 mg/kg bw) and is classified as harmful if swallowed (Xn; R22) according EC criteria (Council Directive 67/548/EEC). Zinc chloride has also demonstrated acute toxicity via the inhalation route (LC50 ≤ 1,975 mg/m3). However, since the exposure of the animals to the size of the particles is not truly representative of exposure to humans under normal conditions, it is difficult to assess whether or not, zinc chloride is acutely toxic since a four hour LC50 value could not be derived and a clear dose-response relationhip coud not be established. Airway irritation has been observed both in animals and in humans, zinc chloride has the potential to be a respiratory tract irritant.

Justification for classification or non-classification

Soluble zinc chloride is harmful following acute oral exposure (LD50 range 1,100 to 1,260 mg/kg bw) and is classified as harmful if swallowed (Xn; R22) according EC criteria (Council Directive 67/548/EEC). Zinc chloride has also demonstrated acute toxicity via the inhalation route (LC50 ≤ 1,975 mg/m3). However, since the exposure of the animals to the size of the particles is not truly representative of exposure to humans under normal conditions, it is difficult to assess whether or not, zinc chloride is acutely toxic since a four hour LC50 value could not be derived and a clear dose-response relationhip coud not be established. Airway irritation has been observed both in animals and in humans, zinc chloride has the potential to be a respiratory tract irritant.

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