Registration Dossier
Registration Dossier
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EC number: 203-742-5 | CAS number: 110-16-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: published result, well documented study
Data source
Reference
- Reference Type:
- publication
- Title:
- Nephrotoxicty of Pravadoline Maeleate (WIN 48098-6) in Dogs: Evidence of Maleic Acid-Induced Acute Tubular Necrosis
- Author:
- Everett RM, Descotes G, Rollin M, Greener Y, Bradford JC, Benzinger DP, Ward SJ
- Year:
- 1 993
- Bibliographic source:
- Fundam. Appl. Toxicol. 21: 59-65
Materials and methods
- Type of study / information:
- Type: other: nephrotoxicity
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Maleic acid
- EC Number:
- 203-742-5
- EC Name:
- Maleic acid
- Cas Number:
- 110-16-7
- Molecular formula:
- C4H4O4
- IUPAC Name:
- but-2-enedioic acid
- Details on test material:
- purity greater than 99.5%
Constituent 1
Results and discussion
Any other information on results incl. tables
No mortality occurred during the 24-h post observation
period. Acute tubular necrosis, characterized by necrosis
of contiguous epithelial cells of the S1, S2, and S3 segments
of the proximal tubules, was observed in all treated
groups. In the lowest dose group, incidence of acute tubular
necrosis was given in 1/3 males and 3/3 females.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
