Registration Dossier
Registration Dossier
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EC number: 203-311-1 | CAS number: 105-58-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: HSDB data (peer reviewed as stated there); original data source from Lewis (1996) could not be reviewed. No details on background data of LDLo value delivered (materials, methods, results).
Data source
Referenceopen allclose all
- Reference Type:
- other: data base data
- Title:
- No information
- Author:
- HSDB
- Year:
- 2 003
- Bibliographic source:
- HSDB database: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
- Reference Type:
- review article or handbook
- Title:
- Sax's Dangerous Properties of Industrial Materials
- Author:
- Lewis, R.J. (ed.)
- Year:
- 1 996
- Bibliographic source:
- 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, p. 1171
Materials and methods
Test material
- Reference substance name:
- Diethyl carbonate
- EC Number:
- 203-311-1
- EC Name:
- Diethyl carbonate
- Cas Number:
- 105-58-8
- Molecular formula:
- C5H10O3
- IUPAC Name:
- diethyl carbonate
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- subcutaneous
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 8 500 mg/kg bw
- Remarks on result:
- other: original as in data source (exposure via subcutaneous route): LD50 Rat scu 8500 mg/kg
Applicant's summary and conclusion
- Conclusions:
- The high LD50 Rat scu 8500 mg/kg suggests a low acute toxicity of diethyl carbonate via the subcutaneous exposure route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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