Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-577-9 | CAS number: 108-39-4
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Remarks:
- repeated dose toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
- Principles of method if other than guideline:
- The reproductive organs were examined as part of the 28-day study.
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- m-cresol
- EC Number:
- 203-577-9
- EC Name:
- m-cresol
- Cas Number:
- 108-39-4
- Molecular formula:
- C7H8O
- IUPAC Name:
- m-cresol
- Details on test material:
- Test substance: purity>98 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Fisher 344/N
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 28 d
- Frequency of treatment:
- continuously in diet
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 300, 1000, 3000, 10000, 30000 ppm
Basis:
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Duration of test: 28 d.
Results and discussion
Observed effects
Any other information on results incl. tables
Histological evaluation , characterized by average severity score based
on a scale of 1 to 4 (1=minimal, 2=mild, 3=moderate, 4= marked) revealed
effects:
Uterine atrophy in 4/5 females at 30000 ppm.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
