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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Remarks:
repeated dose toxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991

Materials and methods

Principles of method if other than guideline:
The reproductive organs were examined as part of the 28-day study.
GLP compliance:
yes
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
m-cresol
EC Number:
203-577-9
EC Name:
m-cresol
Cas Number:
108-39-4
Molecular formula:
C7H8O
IUPAC Name:
m-cresol
Details on test material:
Test substance: purity>98 %

Test animals

Species:
rat
Strain:
other: Fisher 344/N
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
28 d
Frequency of treatment:
continuously in diet
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 300, 1000, 3000, 10000, 30000 ppm
Basis:

Control animals:
yes, concurrent no treatment
Details on study design:
Duration of test: 28 d.

Results and discussion

Observed effects

see any other information on results

Any other information on results incl. tables

Histological evaluation , characterized by average severity score based on a scale of 1 to 4 (1=minimal, 2=mild, 3=moderate, 4= marked) revealed effects:
Uterine atrophy in 4/5 females at 30000 ppm.

Applicant's summary and conclusion