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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: special study with insufficient information

Data source

Reference
Title:
No information
Author:
Shelley WB (1974) p-cresol: cause of ink-induced hair depigmentation in mice. Brit J Dermatol 90: 169-174

Materials and methods

Principles of method if other than guideline:
5 rats, application of the substance to depilated or clipped lower back by mist spray; observation of the hair colour of the new hair regrowth were made weekly.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
m-cresol
EC Number:
203-577-9
EC Name:
m-cresol
Cas Number:
108-39-4
Molecular formula:
C7H8O
IUPAC Name:
m-cresol
Details on test material:
no data on purity

Test animals

Species:
mouse
Strain:
other: CBA/J
Sex:
female

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
6 w
Frequency of treatment:
3 times/week
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 % in acetone
Basis:

Control animals:
yes
Details on study design:
Post-exposure period: 6 months

Results and discussion

Results of examinations

Details on results:
see section "remarks on results"

Any other information on results incl. tables

No depigmentations of the regrowthed hair were observed.

Applicant's summary and conclusion