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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: migrated dataset
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: special study with insufficient information

Data source

Reference
Title:
No information
Author:
Shelley WB (1974) p-cresol: cause of ink-induced hair depigmentation in mice. Brit J Dermatol 90: 169-174

Materials and methods

Principles of method if other than guideline:
Method: other: 5 rats, application of the substance to depilated or clipped lower back by mist spray; observation of the hair colour of the new hair regrowth were made weekly
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
IUCLID4 Test substance: other TS: no data on purity

Test animals

Species:
mouse
Strain:
other: CBA/J
Sex:
female
Details on test animals or test system and environmental conditions:
migrated dataset

Administration / exposure

Details on exposure:
Route of Administration: dermal
Details on analytical verification of doses or concentrations:
migrated dataset
Duration of treatment / exposure:
6 w
Frequency of treatment:
3 times/week
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 % in acetone
Basis:

No. of animals per sex per dose:
migrated dataset
Control animals:
yes
Details on study design:
Post-exposure period: 6 months

Examinations

Observations and examinations performed and frequency:
migrated dataset
Sacrifice and pathology:
migrated dataset
Other examinations:
migrated dataset
Statistics:
migrated dataset

Results and discussion

Results of examinations

Details on results:
migrated dataset: see section "remarks on results"

Effect levels

Dose descriptor:
other: migrated dataset
Effect level:
other: migrated dataset

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
No depigmentations of the regrowthed hair were observed.

Applicant's summary and conclusion

Executive summary:

migrated dataset