m-cresol

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

short-term repeated dose toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: study suffers from deficiencies: only 1 dose used, solvent (aquous glycerol) was not the control, detailed data of the results were not presented, result description did not differ between phenol and m-cresol

Data source

Reference

Title:

No information

Author:

Aerogen Inc. (2001) Inhalation safety of phenol and m-Cresol in rodents: a fourteen day repeat dose toxicity study, study abstract as presented at ISAM Congress 2001

Year:

2001

Materials and methods

Principles of method if other than guideline:

Method: see freetext ME

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

m-cresol

EC Number:

203-577-9

EC Name:

m-cresol

Cas Number:

108-39-4

Molecular formula:

C7H8O

IUPAC Name:

m-cresol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Remarks on MMAD:

MMAD / GSD: migrated dataset

Duration of treatment / exposure:

2 weeks (14 exposures)

Frequency of treatment:

6 hrs/d, 7 d

Doses / concentrations

Remarks:

Doses / Concentrations:
target conc.: 20 ug/l of an 0.25 % solution in 1.6 % aquous glycerol
Basis:

Control animals:

other: yes, water

Details on study design:

Post-exposure period: 2 weeks

Examinations

Observations and examinations performed and frequency:

see section "any other information on material and methods"

Sacrifice and pathology:

see section "any other information on material and methods"

Other examinations:

see section "any other information on material and methods"

Statistics:

see section "any other information on material and methods"

Results and discussion

Any other information on results incl. tables

Observed concentration: 27 ug/l, achieved pulmonary dose level: 690 ug/kg bw no animal died during the study, no treatment related clinical signs; incidental observations in all treatment groups including control groupswere salivation, diarrhea, wet inguinal fur, red material around nose and eyes, alopecia, lesions and red material around nose seen sporadically and in low frequencies during recovery period.
Body weights, body weight gain, hematology, blood chemistry were not statistically different from control group.
Terminal and recovery sacrifices:
No statistically differences in organ weights when compared to controls and no test-article related gross or histopathologic lesions. Observed minor inflammatory or degenerative changes observed in peribronchial, perivascular and subserosal regions were evaluated as incidental findings in rodent inhalation studies.