Registration Dossier
Registration Dossier
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EC number: 203-577-9 | CAS number: 108-39-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no information about strain used, statistical evaluation not given
Data source
Reference
- Reference Type:
- publication
- Title:
- Bio fax data sheet: m-cresol
- Author:
- Industrial Bio-test Laboratory Inc.
- Year:
- 1 969
- Bibliographic source:
- Industrial Bio-test Laboratory Inc, Northbrook, Ill/USA, Data sheet no 3-5/69
Materials and methods
- Principles of method if other than guideline:
- 5 rabbits/dose, 4 doses, exposure time not mentioned, up to 14 days post exposure observation time.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- m-cresol
- EC Number:
- 203-577-9
- EC Name:
- m-cresol
- Cas Number:
- 108-39-4
- Molecular formula:
- C7H8O
- IUPAC Name:
- m-cresol
- Details on test material:
- IUCLID4 Test substance: m-cresol, M.P.: 11-12 C; B.P.: 202.8 C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.29 -2.67 kg
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: none
- Details on dermal exposure:
- no further data
- Duration of exposure:
- no data
- Doses:
- 1000, 1470, 2150, 3160 mg/kg bw.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors and decedents performed: yes
- Other examinations performed: clinical signs, - Statistics:
- yes, method not given.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 050 mg/kg bw
- 95% CL:
- >= 1 590 - <= 2 650
- Remarks on result:
- other: Clinical signs included hypoactivity, salivation, tremors and convulsions; the treated skin showed severe erythema and burns.
- Mortality:
- see section "remarks on results"
- Clinical signs:
- other: see section " remarks on results including tables and figures"
- Gross pathology:
- see sedtion " remarks on results including tables and figures"
- Other findings:
- no data
Any other information on results incl. tables
Dosage onset of symp. mortality mortality
mg/kg 4-12 hrs 12-24 hrs day3 cumulative
100 0 0/5
147 0 0/5
215 0 S 4/5 4/5
316 0 S 4/5 4/5
S = signs of intoxication from 4 hrs up to 12 hrs p.a.: lacrimation,
salivation,
hypersensitivity, convulsion, hypoactivity:
dermal
irritation: severely burned, severe edema
gross necropsy-survivors: no significant findings
gross necropsy-decedents: hyperemia of lungs and kidneys
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
Dermal application of testsubstance to the skin of rabbits and an exposure observation time for 14 days yielded a LD50 of 2050 mg/kg bw and severe irritational effects.
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