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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no information about strain used, statistical evaluation not given

Data source

Reference
Reference Type:
publication
Title:
Bio fax data sheet: m-cresol
Author:
Industrial Bio-test Laboratory Inc.
Year:
1969
Bibliographic source:
Industrial Bio-test Laboratory Inc, Northbrook, Ill/USA, Data sheet no 3-5/69

Materials and methods

Principles of method if other than guideline:
5 rabbits/dose, 4 doses, exposure time not mentioned, up to 14 days post exposure observation time.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
m-cresol
EC Number:
203-577-9
EC Name:
m-cresol
Cas Number:
108-39-4
Molecular formula:
C7H8O
IUPAC Name:
m-cresol
Details on test material:
IUCLID4 Test substance: m-cresol, M.P.: 11-12 C; B.P.: 202.8 C

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.29 -2.67 kg

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: none
Details on dermal exposure:
no further data
Duration of exposure:
no data
Doses:
1000, 1470, 2150, 3160 mg/kg bw.
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors and decedents performed: yes
- Other examinations performed: clinical signs,
Statistics:
yes, method not given.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 050 mg/kg bw
95% CL:
>= 1 590 - <= 2 650
Remarks on result:
other: Clinical signs included hypoactivity, salivation, tremors and convulsions; the treated skin showed severe erythema and burns.
Mortality:
see section "remarks on results"
Clinical signs:
other: see section " remarks on results including tables and figures"
Gross pathology:
see sedtion " remarks on results including tables and figures"
Other findings:
no data

Any other information on results incl. tables

Dosage onset of symp. mortality mortality
mg/kg 4-12 hrs 12-24 hrs day3 cumulative

100       0 0/5
147       0 0/5
215       0 S 4/5 4/5
316       0 S 4/5 4/5

S = signs of intoxication from 4 hrs up to 12 hrs p.a.: lacrimation, salivation,
hypersensitivity, convulsion, hypoactivity:
dermal
irritation: severely burned, severe edema
gross necropsy-survivors: no significant findings
gross necropsy-decedents: hyperemia of lungs and kidneys

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

Dermal application of testsubstance to the skin of rabbits and an exposure observation time for 14 days yielded a LD50 of 2050 mg/kg bw and severe irritational effects.