Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-577-9 | CAS number: 108-39-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: experiments with a m/p-cresol mixture and not with a single isomer
Data source
Reference
- Reference Type:
- publication
- Title:
- Quantitative analysis of cresol and ists metabolites in biological materials and distribution in rats after orál administration
- Author:
- Morinaga Y, Fuke Ch, Arao T, Miyazaki T
- Year:
- 2 004
- Bibliographic source:
- Legal Med 6, 32-40
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Oral application of a cresol soap solution to male rats via gastric tube and examination of cresol content in various tissues at various time points as well as the analysis of the respective glucuronides and sulfates.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- cresol soap solution containing 200 mg/ml p-cresol and 320 mg/ml m-cresol
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: average weight 410 g
- Fasting period before study: 24 hours
- Diet : . ad libitum
- Water :ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
the with water diluted cresol soap solution of which amounts were 2.5 ml/kg (100 mg p-cresol and 160 mg m-cresol) - Duration and frequency of treatment / exposure:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
see above
- No. of animals per sex per dose / concentration:
- no data on number of male rats
- Control animals:
- not specified
- Positive control reference chemical:
- no data
- Details on study design:
- see section " additional information on matereial and method"
- Details on dosing and sampling:
- see section " additional information on matereial and method"
- Statistics:
- see section " additional information on matereial and method"
Results and discussion
- Preliminary studies:
- see section "remarks on results"
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- see section "remarks on results"
- Details on distribution in tissues:
- see section "remarks on results"
- Details on excretion:
- see section "remarks on results"
Metabolite characterisation studies
- Details on metabolites:
- see section "remarks on results"
Any other information on results incl. tables
It was found that cresol administered via the stomach tube diffused directly through the gastric and small intestinal walls because the conjugate cresol concentration were extremely high not only in the liver, but also in the spleen. The unconjugates of cresol in the liver, spleen and kidney were detected in high concentrations even when the unconjugates were not detedcted in the blood. m-Cresol was easily metabolized to sulfate and the p-cresol to glucuronide in rats.The concentration ratios of m-cresol to p-cresol in blood and organs were different from the rate of the cresol soap solution that was administered. The pharmacokinetics was different between p-cresol and m-cresol in rats.
Applicant's summary and conclusion
- Executive summary:
It was found that cresol adinistered via the stomach tube to rats diffused directly through the gastric and small intestinal walls.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
