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Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: experiments with a m/p-cresol mixture and not with a single isomer

Data source

Reference Type:
Quantitative analysis of cresol and ists metabolites in biological materials and distribution in rats after orál administration
Morinaga Y, Fuke Ch, Arao T, Miyazaki T
Bibliographic source:
Legal Med 6, 32-40

Materials and methods

Objective of study:
Principles of method if other than guideline:
Oral application of a cresol soap solution to male rats via gastric tube and examination of cresol content in various tissues at various time points as well as the analysis of the respective glucuronides and sulfates.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
cresol soap solution containing 200 mg/ml p-cresol and 320 mg/ml m-cresol
not specified

Test animals

Details on test animals or test system and environmental conditions:
- Weight at study initiation: average weight 410 g
- Fasting period before study: 24 hours
- Diet : . ad libitum
- Water :ad libitum

Administration / exposure

Route of administration:
oral: gavage
Details on exposure:
the with water diluted cresol soap solution of which amounts were 2.5 ml/kg (100 mg p-cresol and 160 mg m-cresol)
Duration and frequency of treatment / exposure:
Doses / concentrations
Doses / Concentrations:
see above
No. of animals per sex per dose / concentration:
no data on number of male rats
Control animals:
not specified
Positive control reference chemical:
no data
Details on study design:
see section " additional information on matereial and method"
Details on dosing and sampling:
see section " additional information on matereial and method"
see section " additional information on matereial and method"

Results and discussion

Preliminary studies:
see section "remarks on results"

Toxicokinetic / pharmacokinetic studies

Details on absorption:
see section "remarks on results"
Details on distribution in tissues:
see section "remarks on results"
Details on excretion:
see section "remarks on results"

Metabolite characterisation studies

Details on metabolites:
see section "remarks on results"

Any other information on results incl. tables

It was found that cresol administered via the stomach tube diffused directly through the gastric and small intestinal walls because the conjugate cresol concentration were extremely high not only in the liver, but also in the spleen. The unconjugates of cresol in the liver, spleen and kidney were detected in high concentrations even when the unconjugates were not detedcted in the blood. m-Cresol was easily metabolized to sulfate and the p-cresol to glucuronide in rats.The concentration ratios of m-cresol to p-cresol in blood and organs were different from the rate of the cresol soap solution that was administered. The pharmacokinetics was different between p-cresol and m-cresol in rats.

Applicant's summary and conclusion

Executive summary:

It was found that cresol adinistered via the stomach tube to rats diffused directly through the gastric and small intestinal walls.