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Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case report
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: case report

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Brown skin discoloration and black urine along with syncope after dermal exposure of concentrated cresol
Author:
Huang ST
Year:
2012
Bibliographic source:
Journal Emergency Medicine 43, 932-933, 2012
Reference Type:
publication
Title:
black urine after medicinal foot baths
Author:
Liu RL, Huang MY, Huang ST
Year:
2013
Bibliographic source:
BMJ Case Rep 2013. doi:10.1136/bcr-2013-200771

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
dermal absorption
Principles of method if other than guideline:
The case of a 61-year-old male patient who presented to the Emergency Department after dermal exposure with cresol is reported. He had the habit of soaking his feet in cresol-soap solution for 2–3 h three times a week in the last half of the year. This time, he soaked both his feet in a basin filled with 500 mL of 50% cresol-soap solution for 3 h. He was brought to ED by his family.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
all isomers (o-cresol, m-cresol, p-cresol
IUPAC Name:
all isomers (o-cresol, m-cresol, p-cresol
Details on test material:
no data

Method

Subjects:
61-year-old male
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
measured

Results and discussion

Clinical signs:
1) Brownish burns of his feet and black urine after dermal exposure with cresol. 2) Conscious change and syncope. Urine levels of p-cresol, m-cresol, and phenol were 2608, 5391, and 156 mg/g creatinine, respectively, and o-cresol was undetectable at 1 h post-exposure.

Any other information on results incl. tables

The main objective of this report is to provide the characteristic image of cresol poisoning, which may be useful in diagnosis.

Applicant's summary and conclusion

Executive summary:

The case of a 61-year-old male patient who presented to the Emergency Department after dermal exposure with cresol is reported. He had the habit of soaking his feet in cresol-soap solution for 2–3 h three times a week in the last half of the year. This time, he soaked both his feet in a basin filled with 500 mL of 50% cresol-soap solution for 3 h. He was brought to ED by his family.

Results: 1) Brownish burns of his feet and black urine after dermal exposure with cresol. 2) Conscious change and syncope. Urine levels of p-cresol, m-cresol, and phenol were 2608, 5391, and 156 mg/g creatinine, respectively, and o-cresol was undetectable at 1 h post-exposure. 1) Brownish burns of his feet and black urine after dermal exposure with cresol. 2) Conscious change and syncope. Urine levels of p-cresol, m-cresol, and phenol were 2608, 5391, and 156 mg/g creatinine, respectively, and o-cresol was undetectable at 1 h post-exposure.