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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to guideline
Guideline:
EPA OPP 72-2 (Aquatic Invertebrate Acute Toxicity Test)
Deviations:
not specified
Principles of method if other than guideline:
Method: other: US EPA, Methods for acute toxicity test with fish, macroinvertebrates, and amphibians. Nat. Environm. Res. Center, Corvallis (1974)
GLP compliance:
no
Analytical monitoring:
yes
Details on sampling:
daily
Test organisms (species):
Daphnia pulicaria
Test type:
flow-through
Water media type:
freshwater
Limit test:
no
Hardness:
707.3 mg/l CaCO3/l
Test temperature:
14 +/- 1°C
pH:
8.1
Dissolved oxygen:
6.5 mg/l (84.5% saturation)
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 99.5 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
not specified
Conclusions:
The acute toxicity of m-cresol to Daphnia pulicaria was determined in a flow-through immobilisation test after an exposure period of 48 h. Based on measured concentrations a 48h-EC50 > 99.5 mg/l was determined.
Executive summary:

The acute toxicity of m-cresol to Daphnia pulicaria was determined in an experiment under fow-through conditions (DeGraeve, 1980). After an exposure period of 48 h the LC50 was reported to be > 99.5 mg/l. The result relates to measured concentration as analytical control was performed.

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Principles of method if other than guideline:
fertilized eggs exposed to test material
GLP compliance:
no
Analytical monitoring:
yes
Details on sampling:
daily
Vehicle:
no
Test organisms (species):
other: Strongylocentrotus droebachiensis (sea urchin)
Details on test organisms:
fertilized eggs
Test type:
static
Water media type:
saltwater
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
no
Test temperature:
5 °C
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
ca. 30 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
other: development
Remarks on result:
other: sea urchin

NOEC 3 mg/L was next (lower) concentration tested

Executive summary:

The toxicity of m-cresol to the freshly fertilized eggs of the marine sea urchin Strongylocentrotus droebachiensis was determined by a static test. The EC50 (96 h) is 30 mg/L.

Description of key information

The acute toxicity of m-cresol to Daphnia pulicaria was determined in a flow-through immobilisation test after an exposure period of 48 h. Based on measured concentrations a 48h-EC50 > 99.5 mg/l was determined.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
LC50
Effect concentration:
99.5 mg/L

Additional information

Short term toxicity of m-cresol towards various species of aquatic invertebrates was assessed in several experiments.


The acute toxicity of m-cresol to Daphnia pulicaria was determined in an experiment under flow-through conditions. After an exposure period of 48 h the LC50 was reported to be > 99.5 mg/l. The result relates to measured concentration as analytical control was performed.


Another aquatic invertebrate was tested for toxicity. Freshly fertilized eggs of the marine sea urchin Strongylocentrotus droebachiensis were exposed to m-cresol in a static test. The EC50 (96 h) was 30 mg/L.


For risk assessment purposes, only the most reliable study is considered. The study conducted with Daphnia pulicaria was chosen for assessment, as it is the preferred species and the experiments was carried out according to a guideline study, following the state-of-the-art.