Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-577-9 | CAS number: 108-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in air
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in air
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Principles of method if other than guideline:
- Method: other (measured): critical review (data mostly measured according to methods developed by Atkinson and coworkers)
- GLP compliance:
- no
- % Degr.:
- 50
- Sampling time:
- 6 h
- Test condition:
- OH radical conc. 500000 molec/cm³
- Transformation products:
- not measured
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The tropospheric half-life of m-cresol is approximately 6 h due to degradation by OH radicals with an average concentration of 500000 radicals/mL.
- Executive summary:
The tropospheric half-life of m-cresol is approximately 6 h due to degradation by OH radicals with an average concentration of 500000 radicals/mL.
- Endpoint:
- phototransformation in air
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Principles of method if other than guideline:
- Method: other (measured)
- GLP compliance:
- no
- Light spectrum: wavelength in nm:
- ca. 450
- Reference substance:
- yes
- Remarks:
- 1,3-butadiene or o-cresol 0.05-2.3 ppm
- % Degr.:
- 50
- Sampling time:
- 3.8 h
- Test condition:
- OH radical conc. 1000000 molec/cm³
- Transformation products:
- not measured
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- A half-life of 3.8 h at 26°C is calculated for m-cresol from smoke chamber experiments at different tempertures.
- Executive summary:
A half-life of 3.8 h at 26°C is calculated for m-cresol from smoke chamber experiments at different tempertures.
Referenceopen allclose all
K[OH] = 64 [10E-12 cm3 molecule-1 s-1]
K[NO3] = 9.74[10E-12 cm3 molecule-1 s-1]
K[O3] = 1.9 [10E-19 cm3 molecule-1 s-1] With a OH radical concentration of 1 000 000 molec/mL, the
half-life is 3.0 h at room temperature (6 h at 500000 molec/mL)
kOH = 5.17 x 10E-12 exp[(686+-231)/T] cm3 molec.-1 s-1 for a
temperature range of 299-373
With a OH radical concentration of 1 000 000 molec cm-3 and
a temperature of 299 K, the half-life is 3.8 h
Description of key information
The tropospheric half-life of m-cresol is approximately 6 h due to degradation by OH radicals with an average concentration of 500000 radicals/mL .
An even shorter half-life of 3.8 h is calculated for m-cresol from smoke chamber experiments at different tempertures.
Key value for chemical safety assessment
- Half-life in air:
- 6 h
- Degradation rate constant with OH radicals:
- 0 cm³ molecule-1 s-1
Additional information
In the atmosphere, m-cresol will react with photochemically produced hydroxyl-radicals. In his critical review Atkinson recommended values for the reaction constant kOH at room temperature of 6.4 x 10-11 cm³ x molecule-per second. Based on a tropospheric OH radical concentration of 5 x 105molecules per cm³ a corresponding half-life of 6.0 h can be calculated.
In an experiment the temperature dependency of the reaction constants in a smog chamber was determined. The calculated half-life is 3.8 h for m-cresol at 23°C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.