Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 208-754-4 | CAS number: 540-72-7
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The study does not meet the current guideline and was not performed under GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test material
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
In examinations of the bone-marrow as well as germ cells of 2 strains of mice (ICR, CFLP) was found that NaSCN applied at a dose of 64 mg/kg daily on 3 consecutive days significantly decreases the frequency of the chromosome aberrations evoked by cyclophosphamide, from 68% to 52% in the bone-marrow cells ( α <1%) and from 25% to 16% in the germ cells (α < 5%). With regard to the medical and biological importance of the thiocyanates it seems promosing to subject these findings to a deeper treatment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
