Registration Dossier
Registration Dossier
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EC number: 208-754-4 | CAS number: 540-72-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 1965-1972
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study was not performed according to guideline or under GLP. Limited reporting. IP route.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- GLP compliance:
- no
Test material
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 5.1-5.9 mmmol/kg
- No. of animals per sex per dose:
- approximately 10
- Control animals:
- no
Results and discussion
Applicant's summary and conclusion
- Executive summary:
In toxic doses administered IP sodium cyanate and thiocyanate produce similar syndromes in mice: tremor, hyper-reactivity and tonic-clonic convulsions. A common pattern of interactions with central nervous system drugs suggests that these anions have similar mechanisms of action. Thiocyanate had highly unpredictable lethal effects. The range of doses which included some deaths and some survivors in each group (at least 10 mice) was 5.1 to 7.9 mmol/kg.
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