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Toxicity to soil macroorganisms except arthropods

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Description of key information

NOEC (28 d, mortality) and NOEC (56 d, reproduction) ≥1000 mg/kg soil dw (nominal) (Eisenia fetida, OECD 222) (read-across)

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Additional information

In accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally similar analogue substance dipentaerythritol hexa esters of pentanoic, heptanoic and trimethylhexanoic acid (CAS 67762-52-1) was conducted to fulfil the data requirements according to Annex VII - IX of dipentaerythritol ester of nC5/iC9 acids (CAS 647028-25-9) in regard to long-term toxicity to soil macroorganisms.

This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID section 13. The source substances consist of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths as the target substance (C5-9iso for the target substance compared to C5-9 for the source substances, respectively).

The study used for read across was performed according to OECD 222 under GLP conditions (Eisner, 2013). Eisenia fetida were exposed to nominal concentrations of 62.5, 125, 250, 500 and 1000 mg/kg dry soil. The total exposure period was 56 days. After 28 days the adult earthworms were removed and the cocoons and juveniles remained in the test substrate for another 28 days. Acetone was used as vehicle during test item preparation and evaporated before application. No mortality or adverse effects on reproduction were observed. Therefore, both the NOEC for mortality (28 d) and the NOEC for reproduction (56 d) were determined to be ≥1000 mg/kg soil dw.

Based on the result from the structurally related read-across substance dipentaerythritol hexa esters of pentanoic, heptanoic and trimethylhexanoic acid (CAS 67762-52-1) it can be concluded that dipentaerythritol ester of nC5/iC9 acids (CAS 647028-25-9) will not exhibit toxic effects to Eisenia fetida.