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Long-term toxicity to aquatic invertebrates

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Description of key information

EL10 and EL50 (21 d) >100 mg/L (nominal) (Daphnia magna, OECD 211)
NOELR (21 d) ≥100 mg/L (nominal) (Daphnia magna, OECD 211)
No effects up to the limit of the water solubility of the substance (read-across)

Key value for chemical safety assessment

Additional information

In accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally similar analogue substance dipentaerythritol hexa esters of pentanoic, heptanoic and trimethylhexanoic acid (CAS 67762-52-1) was conducted to fulfil the data requirements according to Annex VII - IX of dipentaerythritol ester of nC5/iC9 acids (CAS 647028-25-9) in regard to long-term toxicity to invertebrates.

This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID section 13. The source substances consist of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths as the target substance (C5-9iso for the target substance compared to C5-9 for the source substances, respectively).

The study used for read across was performed according to OECD 211 under GLP conditions (Ablitt, 2015). Daphnia magna were exposed to water accommodated fractions (WAFs) with a nominal loading rates of 1, 10, and 100 mg/L in a semi-static test for 21 d. The test substance loading rates were analysed using HPLC-MS-analysis. Chemical analysis of the fresh and aged test preparations showed measured test concentrations ranging from <LOQ to 0.0269 mg/L and <LOQ to 0.0240 mg/L, respectively. No mortality or adverse effects on mobility and reproduction were observed. Therefore, for reproduction the EL10 and EL50 were determined to be > 100 mg/L (nominal). The NOELR and the LOELR were determined to be ≥100 mg/L and >100 mg/L, respectively

Based on the result from the structurally related read-across substance dipentaerythritol hexa esters of pentanoic, heptanoic and trimethylhexanoic acid (CAS 67762-52-1) it can be concluded that dipentaerythritol ester of nC5/iC9 acids (CAS 647028-25-9) will not exhibit long-term toxic effects to Daphnia up to the limit of water solubility.