Registration Dossier
Registration Dossier
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EC number: 306-479-5 | CAS number: 97280-83-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Ames Test:
The potential of the test item to induce mutagenicity in bacteria (strains: S. typhimurium TA 1535, TA 1537, TA 98 and TA 100) was assessed according to OECD guideline 471 (BASF AG, 1989). In the first experiment, all bacteria strains were incubated with 20-5000 µg/plate of test substance, in the second experiment only the TA1537 strain was incubated with 20-7500 µg/plate in a standard plate test with and without metabolic activation. The third experiment comprised all three strains of bacteria using the pre-incubation test with and without activation.
A weakly bacteriotoxic effect (reduced his background growth, slight decrease in the number of his+ revertants) was only observed in the pre-incubation test without S-9 mix using TA 100 at 5000 µg/plate and with TA 1537 from about 500 µg/plate onwards. According to the results of the present study, the test substance isododecene is not mutagenic in the Ames test. The slight and not dose-dependent increase in the number of revertant colonies using the strain TA 1537 in the 1ststandard plate test with S-9 mix could not be confirmed either in a 2nd standard plate test including higher doses or in a pre-incubation assay. Thus, the findings of the test study with TA 1537 are regarded as incidental and isododecene hence not classified as mutagenic.
Short description of key information:
Ames test (OECD471): negative (BASF AG, 1989)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available results, the test item does not warrant classification according to Directive 67/548/EEC and ES1272/2008 (CLP).
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