Registration Dossier
Registration Dossier
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EC number: 417-560-0 | CAS number: 67881-98-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Letter of Access (See Section 13)
- Adequacy of study:
- key study
Data source
Reference
- Reference Type:
- other: Letter of Access (See Section 13)
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- not specified
- Remarks:
- Letter of Access only
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 417-560-0
- EC Name:
- -
- Cas Number:
- 67881-98-5
- Molecular formula:
- C11H22NO6P
- IUPAC Name:
- trimethyl[2-({2-[(2-methylprop-2-enoyl)oxy]ethyl phosphonato}oxy)ethyl]azanium
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 5 animals of each sex were tested during this study.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Doses:
- Each test animan was dosed with 2000 mg/kg HEMA-PC
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No 95% CL available due to results
- Mortality:
- No mortalities were observed during this study.
- Clinical signs:
- other: Pilo erection was observed in all rats within five minutes of dosing. This was accompanied at later intervals on day 1 by abnormal body carriage (hunched posture) Recovery of all animals was complete by day 2.
- Gross pathology:
- No abnormalities were recorded at the macroscopic examination on day 15.
Any other information on results incl. tables
Table 1. Results of Acute Toxicity: Oral Test
Sex |
Dose (mg/kg) |
Number of Animals |
Number of Deaths |
Male |
2000 |
5 |
0 |
Female |
2000 |
5 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The results of this study indicate that HEMA-PC is not classified as toxic, as the LD50 was determined to be >2000 mg/kg HEMA-PC.
- Executive summary:
The oral acute toxicity of HEMA-PC was conducted using EU Method B.1 (Acute Toxicity - Oral).
The results of this study indicate that HEMA-PC is not classified as toxic, as the LD50 was determined to be >2000 mg/kg HEMA-PC.
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