Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
other: Not applicable since exclusively summarizing data coming from a existing risk assessment (BUA Report) are presented as executive summary.

Data source

Reference Type:
other: Risk assessment
Phenylenediamines, BUA Report 97
GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Bibliographic source:
edited by the GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance, S. Hirzel, Wissenschaftliche Verlagsgesellschaft, Birkenwaldstraße 44, 70191 Stuttgart, 1995

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

There are no recent and adequately documented studies on the toxicity after repeated administration. In the context of an inadequately documented carcinogenicity study in rat and mouse no striking mortality was described after dosages of 300 and approx. 2000 mg o-phenylenediamine x 2 HCl/kg bw.