Registration Dossier
Registration Dossier
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EC number: 202-180-8 | CAS number: 92-70-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract information in OECD SIDS report of 2004; study described in OECD SIDS as valid with restrictions as limited scope of clinical/organ/tissue examinations
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 19 - 3-Hydroxy-2-naphthoic acid
- Author:
- Anonymous
- Year:
- 2 004
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- Molecular formula:
- C11H8O3
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
- Details on test material:
- 98.5% purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- 7 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0; 12; 60; 300 mg/kg bw
Basis:
no data
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Details on results:
- Decreased serum phosphate levels were observed in both sexes at a dose level of 300 mg/kg bw. The toxicological relevance of this finding is unclear. At 300 mg/kg, increased bilirubin concentrations were found in serum and urine, which may be indicative for a hepatotoxic action of the test compound. Females showed slightly increased liver weights, but without microsocpic correlates. Necroses of the adrenal cortex were found in one female each of the mid- and high-dose group.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 12 mg/kg bw/day (nominal)
- Sex:
- female
- Dose descriptor:
- NOAEL
- Effect level:
- 60 mg/kg bw/day (nominal)
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
