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EC number: 210-258-8 | CAS number: 611-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Method: T09-02: FIFRA Pesticide Assessment Guidelines, Subdivision F, Section 81-2; "Acute Dermal Toxicity Study "TSCA Health Effects Test Guidelines; " Acute Exposure, Dermal Toxicity"
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- α,2-dichlorotoluene
- EC Number:
- 210-258-8
- EC Name:
- α,2-dichlorotoluene
- Cas Number:
- 611-19-8
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 1-chloro-2-(chloromethyl)benzene
- Details on test material:
- Source: Monsanto Company- Lot/Batch No.: 3168723, 2503577
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: at least 8 weeks old at study initiation
- Weight at study initiation: 2.5 kg to 3.1 kg
- Fasting period before study: no data
- Housing: individually, stainless steel cages with wire mesh bottoms
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 60 - 70 F (ca. 16 - 21 °C)
- Humidity (%): 30 - 70%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- One day before dosing, the hair of each rabbit was closely clipped from the dorsal area of the trunk with electric clipper,
so as to expose at least 10% of the body surface area. Care was taken to avoid abrading the skin.
Only animals with intact, healthy skin were used.
The test substance was applied directly onto exposed skin and spread evenly over the entire area.
Gauze was then wrapped around the animal to cover the application site.
The animal was then wrapped in an impervious plastic sleeve, designed to contain the test substance
without leakage or undue pressure. The sleeve was secured with tape and Elizabethan collars
were placed on all animals to prevent ingestion of the test substance or disruption of the wrappings. - Duration of exposure:
- period of 24 h
- Doses:
- 1000, 2000, and 4000 mg/kg bw
- No. of animals per sex per dose:
- 5 (Fifteen male and 15 female New Zealand rabbits)
- Control animals:
- no
- Details on study design:
- Animals were observed at approximately 1, 2, and 4 hours after application and daily thereafter for fourteen days.
Gross necropsy was performed on all animals which died or were found dead during the study.
All animals surviving at the end of the observation period were sacrificed and necropsied
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 769 - < 2 631
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 022 - <= 3 378
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 287 - 2 513
- Mortality:
- No animal death was observed at 1000 mg/kg bw during 14-day observation period. Four males and two females died at 2000 mg/kg by Day 3, and all animals were dead at 4000 mg/kg by Day 7.
- Clinical signs:
- other: The majority of animals at 2000 and 4000 mg/kg exhibited decreased activity and food consumption beginning 4 or 24 hours after administration. Other abnormalities seen in these groups, often as antemortem signs in animals which died, included ataxia, trem
- Gross pathology:
- Gross necropsies of animals founded dead revealed a number of abnormalities (red foci and/or discoloration of lungs, white patches of liver,
extremely large gall bladder, reddened or swollen uterus, testes found in body cavity, red walls of stomach and intestine and black foci
in stomach walls), most of which appeared to represent postmortem autolytic changes.
Observations in animals sacrificed at Day 14 confirmed the presence of dermal lesions (necrosis following by eschar formation, fissuring
and/or exfoliation of the eschar tissue), and no other abnormalities related to administration were observed.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information R21: Harmful in contact with skin / GHS Cat.4 Criteria used for interpretation of results: EU
- Conclusions:
- o-Chlorobenzylchloride is harmful in contact with skin.
- Executive summary:
In an acute dermal toxicity study, groups of New Zealand Rabbits (5/sex) were dermally exposed to o-Chlorobenzylchloride to expose at least 10% of the body surface area at doses of 1000, 2000, and 4000 mg/kg bw. No animal death was observed at 1000 mg/kg during 14-day observation period. Four males and two females died at 2000 mg/kg bw by Day 3, and all animals were dead at 4000 mg/kg by Day 7. The majority of animals at 2000 and 4000 mg/kg bw exhibited decreased activity and food consumption beginning 4 or 24 hours after administration. Other abnormalities seen in these groups included ataxia, tremors, hypopnea, hypothermia, nasal discharge, unthrify coats and urinary and fecal staining. Survivors (in the 2000 mg/kg bw group) were free of signs of systemic toxicity by day 10. The only systemic abnormalities seen in the 1000 mg/kg bw group were isolated occurrences of decreased activity and food consumption in one or two animals through day 7. Most surviving animals exhibited severe dermal effects at the dose site which persisted throughout the study. Gross necropsies of animals founded dead revealed a number of abnormalities, most of which appeared to represent postmortem autolytic changes. Observations in animals sacrificed at day 14 confirmed the presence of dermal lesions, and no other abnormalities related to administration were observed.
Dermal LD50 Males = 1700 mg/kg (95% confidence limits: 769-2631 mg/kg)
Dermal LD50 Females = 2200 mg/kg (95% confidence limits: 1022-3378 mg/kg)
Dermal LD50 Combined = 1900 mg/kg (95% confidence limits: 1287-2513 mg/kg)
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