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EC number: 231-748-8 | CAS number: 7719-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: read-across from the hydrolysis product of SOCl2 (HCl)
- Adequacy of study:
- key study
- Study period:
- Not specified; published in 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Sex, weight, and source of the animals as well as individual observations are not reported. Source and purity of test material are not reported. However, results following an OECD guideline show eye damage fully compatible with instillation of a strong acid; these results provide clear indication that the a.i. is likely corrosive and that no further animals should be tested for this endpoint.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- (1981)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydrogen chloride
- EC Number:
- 231-595-7
- EC Name:
- Hydrogen chloride
- Cas Number:
- 7647-01-0
- IUPAC Name:
- chloride
- Details on test material:
- Hydrochloric acid aqueous solution at 10% .
No further details specified.
Constituent 1
Test animals / tissue source
- Species:
- other: Rabbit (Albino)
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: not stated
- Age at study initiation: not stated
- Weight at study initiation: not stated
- Housing: not stated
- Diet (e.g. ad libitum): not stated
- Water (e.g. ad libitum): not stated
- Acclimation period: not stated
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not stated
- Humidity (%): not stated
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): not stated
IN-LIFE DATES: not stated
Test system
- Vehicle:
- water
- Controls:
- other: untreated eye served as control. No control animals were used.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL aqueous solution
- Concentration (if solution): 10% in water
VEHICLE
No details specified. - Duration of treatment / exposure:
- Single exposure in the lower conjunctival sac.
- Observation period (in vivo):
- 96 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Examination time points: 4, 24, 48, 72 and 96 hours post-treatment.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
- Time after start of exposure: not specified
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: application of one drop fluorescein 2% before visual scoring of percentage corneal damage.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72 and 96 hrs
- Score:
- >= 1.9 - <= 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other: Scoring up to 96 hours post-treatment
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72 and 96 hrs popst treatment
- Score:
- >= 1 - <= 2.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: scoring up to 96 hrs post treatment
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72 and 96 hours post treatment
- Score:
- >= 1 - <= 1.7
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- other: scoring up to 96 hrs post treatment
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72 and 96 hrs post treatment
- Score:
- >= 1.3 - <= 3.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: scoring up to 96 hrs post treatment
- Irritation parameter:
- cornea opacity score
- Remarks:
- damage
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72 and 96 hours post treatment
- Score:
- >= 15 - <= 59
- Max. score:
- 100
- Reversibility:
- not fully reversible within: 96 hours
- Remarks on result:
- other: scoring up to 96 hrs post treatment
- Irritant / corrosive response data:
- Results are reported in "Remarks on results including tables and figures".
- Other effects:
- Not stated.
Any other information on results incl. tables
Results of eye irritation study
Time after application (hrs) |
4 |
24 |
48 |
72 |
96 |
Mean score of conjunctivitis(maximum 3) |
1.9 |
2.8 |
3.0 |
3.0 |
2.9 |
Mean score of chemosis(maximum 4) |
1.0 |
1.7 |
2.3 |
2.3 |
2.0 |
Mean score of iritis(maximum 2) |
1.0 |
1.3 |
1.7 |
1.7 |
1.7 |
Mean score of corneal opacity(maximum 4) |
1.3 |
2.0 |
2.7 |
3.3 |
3.0 |
Mean score of corneal damage(maximum 100%) |
15 |
59 |
49 |
42 |
28 |
Summary of results and discussion:
HCl applied as an aqueous solution at a percentage of 10% was classified as “Risk of serious damage to eyes” according to the 83/467/criteria (mean over 24/48/72 hrs of iritis >1.5).
Applicant's summary and conclusion
- Interpretation of results:
- other: Risk of serious damage to eyes
- Remarks:
- Criteria used for interpretation of results: other: 83/467/EEC criteria (mean over 24/48/72 hrs of iritis >1.5)
- Conclusions:
- HCl applied as an aqueous solution at a percentage of 10% was classified as “Risk of serious damage to eyes” according to the 83/467/EEC criteria (mean over 24/48/72 hrs of iritis >1.5).
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