(Z)-N-octadecyldocos-13-enamide

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

activated sludge respiration inhibition testing

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the analogue justification attached to IUCLID section 13.

Reason / purpose for cross-reference:

read-across: supporting information

Duration:

3 h

Dose descriptor:

EC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Remarks:

respiration rate

Duration:

3 h

Dose descriptor:

NOEC

Effect conc.:

>= 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Remarks:

respiration rate

Conclusions:

EC50 (3 h) > 1000 mg/L (OECD 209)

Executive summary:

No data are available on the toxicity of (Z)-N-Octadecyldocos-13-enamide (CAS No. 10094-45-8) towards aquatic microorganisms. Therefore data from the analogue substance (Z)-N-octadec-9-enylhexadecan-1-amide (oleyl palmitamide, CAS 16260-09-6) were used as read across.

The toxicity of (Z)-N-octadec-9-enylhexadecan-1-amide (oleyl palmitamide, CAS 16260-09-6) to aquatic microorganisms was investigated in one respiration inhibition test according to OECD guideline 209 under GLP conditions (Roulstone, 2012). Predominantly domestic activated sludge was incubated with test item concentrations of 10, 100 and 1000 mg/L. The highest test concentration was prepared in triplicate while the two lower concentrations were single preparations. No statistically significant toxic effects of the test item were shown at all test concentrations employed. Therefore, an EC50 (3 h) > 1000 mg/L and a NOEC≥ 1000 mg/L were assumed.

Furthermore, a ready biodegradability test conducted in accordance to RDA (Repetitive Die Away) test on theanalogous substance CAS No. 13276-08-9, which includes a toxicity control. The results of this test indicate that the test substance is not toxic to the sewage treatment microorganisms at a concentration of 39 mg/L.

Description of key information

EC50 (3 h) > 1000 mg/L (OECD 209)

Additional information

No data are available on the toxicity of (Z)-N-Octadecyldocos-13-enamide (CAS No. 10094-45-8) towards aquatic microorganisms. Therefore data from the analogue substance (Z)-N-octadec-9-enylhexadecan-1-amide (oleyl palmitamide, CAS 16260-09-6)were used as read across. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 and justified in detail in the overall summary (IUCLID Chapter 6.1) and within the analogue justification attached in IUCLID Section 13.

The toxicity of (Z)-N-octadec-9-enylhexadecan-1-amide (oleyl palmitamide, CAS 16260-09-6) to aquatic microorganisms was investigated in one respiration inhibition test according to OECD guideline 209 under GLP conditions (Roulstone, 2012). Predominantly domestic activated sludge was incubated with test item concentrations of 10, 100 and 1000 mg/L. The highest test concentration was prepared in triplicate while the two lower concentrations were single preparations. No statistically significant toxic effects of the test item were shown at all test concentrations employed. Therefore, an EC50 (3 h) > 1000 mg/L and a NOEC≥ 1000 mg/L were assumed.

Furthermore, a ready biodegradability test conducted in accordance to RDA (Repetitive Die Away) test on the analogous substance CAS No. 13276-08-9, which includes a toxicity control. The results of this test indicate that the test substance is not toxic to the sewage treatment microorganisms at a concentration of 39 mg/L.