Registration Dossier
Registration Dossier
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EC number: 201-187-3 | CAS number: 79-22-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- diferent concentrations of the testsubstance were injected i.p. into mice
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Methyl chloroformate
- EC Number:
- 201-187-3
- EC Name:
- Methyl chloroformate
- Cas Number:
- 79-22-1
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- methyl chloroformate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 0.0681-3 .16% aqueous solution
- Control animals:
- not specified
- Details on study design:
- Determination of the approximative median lethal dose or LD50 calculated according to LITCHFIELD-WILCOXON
- Duration of observation period following administration: 14
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- ca. 9 other: µl
- Clinical signs:
- Dyspnea; apathy; staggering in some cases; twitching in some cases; poor general sate
- Gross pathology:
- Intraabdominal adhesions sporadically
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
