Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-187-3 | CAS number: 79-22-1
Phototransformation in air
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound methyl chloroformate (CAS 79 -22 -1): After evaporation or exposure to air, the substance will be slowly degraded by photochemical processes. This estimate refers to dry air. In mist, rain, droplets and aerosols, hydrolysis will be the major fate process of the chloroformate due to the short half-life in aqueous solution. Therefore this estimate may be of low relevance.
Hydrolysis product methanol (CAS 67 -56 -1): After evaporation or exposure to air, the substance will be slowly degraded by photochemical processes.
Key value for chemical safety assessment
Additional information
Parent compound methyl chloroformate:
Based on an estimated OH radical rate constant of 2.176E-13 cm3/(molecule*sec), the half-life of methyl chlorformate was calculated to be 73.7 days (conditions: sensitiser for indirect photolysis: OH; 0.5 E06 OH/cm3, 24-h d; BASF SE, 2019). Based on the EPI Suite calculation the substance will be slowly degraded by photochemical processes, after evaporation or exposure to air. This estimation refers to dry air. In mist, rain, droplets and aerosols, hydrolysis will be the major fate process of the chloroformate due to the short half-life in aqueous solution. Therefore this estimate may be of low relevance.
Hydrolysis product methanol:
Based on a measured OH-radical rate constant of 9.32E-13 cm3/(molecule*sec), the half-life of methanol was calculated to be 17.2 days (conditions: sensitiser for indirect photolysis: OH; Atkinson, 1989; peer-reviewed data OECD, 2004). Based on the available measured data the substance will be slowly degraded by photochemical processes, after evaporation or exposure to air.
QSAR-disclaimer:
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of methyl chloroformate (CAS 79-22-1) (Q)SAR results were used for phototransformation in air.
The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint is sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on phototransformation in air are not provided.
Conclusion:
Based on the available calculated and experimental data for the parent itself and int metabolite product, it can be concluded, that both substances will be slowly degraded by photochemical processes, after evaporation or exposure to air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
