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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1. September1988 - 15. September 1988
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
adopted May 12, 1981
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
Pow
Partition coefficient:
< 0.02
Temp.:
20 °C
pH:
7.4
Key result
Type:
log Pow
Partition coefficient:
< -1.7
Temp.:
20 °C
pH:
7.4

From the preliminary test a partition coefficient of 0.07 was calculated (test substance concentrations of 5 microg/ml (detection limit) and 69 microg/ml were calculated for the n-octanol and buffer phase, respectively).

The analytical procedure as outlined in section 3.4 was found to be linear between 120 microg/ml and 10 microg/ml and its detection limit was found to be 5 microg/ml The test substance was determined to be stable for at least 4 hours in Milli-Q water (results not shown).

Concentrations of test substance in buffer and n-octanol samples were calculated using the absorbance coefficient at 480 nm in Milli-Q.

An overall partition coefficient of < 0.02 was calculated. Expressed as its logarithm (base 10), the mean partition coefficient is < -1.70; individual values fall within the range of ± 0.3 log units and therefore meet the quality criterion. Temperature of measurement was 20 ± 1°C. pH values of the water phases are shown in Table 1; pH of the buffer solution was 7.4.
 In conclusion, the partition coefficient (n-octanol/water) for Guanidine Hydrochloride was determined to be < 0.02 (log pow: < -1.70) at 20 ± 1°C.

Conclusions:
In a test according to OECD 107, Guanidine hydrochloride showed a log Kow < -1.70 (20 °C, pH 7.4).
Executive summary:

In a test according to OECD 107, Guanidine hydrochloride showed a log Kow < -1.70 (20 °C, pH 7.4).

Description of key information

In a test according to OECD 107 Guanidine hydrochloride showed a log Kow < -1.70 (20 °C, pH 7.4).

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.7
at the temperature of:
20 °C

Additional information