Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published protocol and summary of results is all that is available.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1986

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method C.2 (Acute Toxicity for Daphnia)
Deviations:
not specified
Principles of method if other than guideline:
Protocol according to Ewell, W.S., Gorsuch, J.W., Kringle, R.O., Robillard, K.A., and Spiegal, R.C. Simultaneous evaluation of the acute effects of chemicals on seven species. Environmental Toxicology and Chemistry. 5:831-840. 1986.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Propanoic acid, 2-methyl-, 1,1'-[2,2-dimethyl-1-(1-methylethyl)-1,3-propanediyl] ester
IUPAC Name:
Propanoic acid, 2-methyl-, 1,1'-[2,2-dimethyl-1-(1-methylethyl)-1,3-propanediyl] ester
Constituent 2
Chemical structure
Reference substance name:
1-isopropyl-2,2-dimethyltrimethylene diisobutyrate
EC Number:
229-934-9
EC Name:
1-isopropyl-2,2-dimethyltrimethylene diisobutyrate
Cas Number:
6846-50-0
Molecular formula:
C16H30O4
IUPAC Name:
2,2,4-trimethyl-1-[(2-methylpropanoyl)oxy]pentan-3-yl 2-methylpropanoate
Constituent 3
Reference substance name:
2,2,4-Trimethylpentanediol-1,3-diisobutyrate
IUPAC Name:
2,2,4-Trimethylpentanediol-1,3-diisobutyrate
Constituent 4
Reference substance name:
Texanol isobutyrate; TXIB
IUPAC Name:
Texanol isobutyrate; TXIB
Details on test material:
-Test substance (name as cited in study report): Eastman TXIB
-Source of test material: Eastman Chemical Company
-Purity: >98%
-Production date: 4/26/07
-Date of receipt: 7/26/07
-Stability: 1 year
-Storage: Room temperature and humidity
-Description: Clear liquid
-Specific gravity: 0.92

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Details on test solutions:
Summary indicates that the test was conducted on a saturated solution (limit of water solubility)

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 1.46 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 1.46 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
Study evaluated 7 species simultaneously. Summary indicates that the test was conducted using a saturated solution (limit of water solubility). Concentration reported for 48-hour daphnia endpoint in this study listed concentration as 1.46 mg/L while 96 hour results were listed as 1.55 mg/L which suggests that the concentrations were measured. Other studies following the same protocol that included full study details indicate measured concentrations as standard procedure.
Reported statistics and error estimates:
No adverse effects reported.

Applicant's summary and conclusion

Executive summary:

Company data provided in the form of a results summary. The protocol for the study method is published and similar to the EU Method C.2 protocol for daphnia. The methods used for this study are well documented in full study reports for other test substances. While a study report is not available for this test substance, the results are considered to be reliable for a weight of evidence report supported by more recent GLP studies. The results support a conclusion that acute effects for daphnia are not expected at the limit of water solubility.