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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Administrative data

Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

The available data on carcinogenicity of the test substance does not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and is therefore conclusive but not sufficient for classification.

Additional information

Propylparaben was not genotoxic in several Ames tests and a HPRT test (Brusick, 1975; McCann et al., 1975; Wollny, 2012) and In vitro mammalian micronucleus Test (OECD 487, 2018). Moreover, there are studies available, investigating hyperplasia of the forestomach in rats and hamsters after treatment with propylparaben for 8 and 20 weeks, respectively. No hyperplasia was observed in any of the studies. In a subchronic study in rats and chronic studies in rats and dogs, no evidence for preneoplastic and neoplastic lesions were noted (Harlan, 2012; Matthews et al., 1956). Based on all available data, propylparaben is considered to have no carcinogenic potential.