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EC number: 202-307-7 | CAS number: 94-13-3
Parabens are commonly used as antimicrobial preservatives in consumer products. Although pharmacokinetic studies on
parabens have been conducted in animals, limited information exists on their pharmacokinetic profiles in humans.
In the present study, the pharmacokinetic characteristics of propyl paraben (PP) in humans
following a single oral administration of 0.6 mg/kg bw of deuterium labeled-PP was investigated. furthermore another experiment was conducted with similar design but different exposure amount (2.5 mg/kg bw) to verify the validity of the model to be developed. Blood and urine were collected at several intervals over the course of 48 h to measure levels of PP and its metabolites (conjugates and hydrolysates) in 12 male volunteers. The unconjugated parent compound (free PP), glucuronide and sulfate conjugates, p-hydroxybenzoic acid, and p-hydroxyhippuric acid were measured using HPLC-MS/MS.
It was found that PP was rapidly absorbed via ingestion within 2 h and quickly eliminated
(terminal half-life, 2.9 h). The fraction of administered dose excreted in the urine was 0.05% for free PP, 8.6% for
total PP (free + conjugates), 23.2% for p-hydroxyhippuric acid, and 7.0% for p-hydroxybenzoic acid.
The present pharmacokinetic model provides insights into the kinetic properties of the disposition of PP
and its metabolites in humans, and it can be used for risk assessment with biomonitoring of PP.
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