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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Structure-Toxicity Relationship of Acrylic|Monomers.
Author:
Autian J
Year:
1975
Bibliographic source:
Environmental Health Perspectives 11: 141-152 [Review]
Reference Type:
publication
Title:
Development of a|Toxicity Evaluation Program for Dental Materials and|Products.
Author:
Lawrence WH, Malik M, Autian J
Year:
1974
Bibliographic source:
J. Biomed. Mat. Res. 8: 11-34

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
ethyl methacrylate, purity: no data

Commercial source: Rohm & Haas Philadeliphia, Pa.
The substance contained from 5 to 2000 ppm of polymerization inhibitor, monomethyl ether of hydroquinone,
or 100 ppm hydroqunione. The monomer was used as such with no further purification. No more data available.

Test animals

Species:
mouse
Strain:
ICR
Sex:
male
Details on test animals and environmental conditions:
The test animals were 25 +/- 5 gm, male albino ICR mice.

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on study design:
 Several dose  levels of each compound were injected intraperitoneally into groups of  ten mice and the mice were observed for 7 days for mortality. Injections  were made with a clinical syringe when the dose to be 
administered was  greater than 1 ml. With a dose of 0.1 to 1.0 ml a tuberculin syringe was  used, and for doses of less than 0.1 ml a Hamilton microliter syringe was  used.
Statistics:
Acute LD50-values and 95 % confidence limits were calculated by Cornfield  and Mantel's modification of Karber's method.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 247 mg/kg bw
Remarks on result:
other: Original value: 1.369 ml/kg equals 10.896 mol/10+6 gm (9.328 - 12.734  mol/10+6 gm) 95 % confidence limit) Density: 0.911 g/cm3

Applicant's summary and conclusion